We Are Located In North Palm Beach
Our U.S. Highway 1 location at 635 U.S. Highway 1 is in the heart of North Palm Beach, surrounded by coastal neighborhoods, shopping centers, and local businesses. Whether you’re coming from nearby Jupiter, Palm Beach Gardens, or surrounding communities, it’s easy to reach and perfect for dine-in or takeout.
Welcome To DeSano Pizzeria Napoletana
Address: 635 U.S. Hwy 1, North Palm Beach, FL 33408, United States
Phone: +1 561-337-4996
Hours:
Monday 11:30 AM–9 PM
Tuesday 11:30 AM–9 PM
Wednesday 11:30 AM–9 PM
Thursday 11:30 AM–9 PM
Friday 11:30 AM–9 PM
Saturday 11:30 AM–9 PM
Sunday 11:30 AM–9 PM
Crafted With Fire And Italian Tradition
Every creation begins with carefully prepared dough, aged for depth and character, then topped with premium imported ingredients sourced directly from Italy. Fired in authentic wood-burning ovens built with volcanic stone, each pie emerges with a lightly blistered crust, airy interior, and rich layers of flavor.
The balance of simplicity and craftsmanship defines every plate—rustic yet refined, bold yet elegant. This is Italian tradition expressed through fire, time, and precision.
Authentic Neapolitan Excellence & Five-Star Local
Our North Palm Beach guests consistently praise the authentic Italian craftsmanship found in every wood-fired pie. Semantic analysis of recent reviews reveals a deep appreciation for our imported ingredients, specifically the San Marzano tomatoes and buffalo mozzarella. Patrons frequently highlight the welcoming, airy atmosphere created by our signature garage doors and the social, family-friendly vibe that makes us a neighborhood staple for both casual dinners and celebrations.
Order From Our Website
Enjoy the same wood-fired craftsmanship from the comfort of your home. Place your order directly through our website for convenient pickup or delivery at your nearest location. Freshly prepared, carefully packaged, and ready when you are.
Flavors In Focus
Experience the visual story of authentic Neapolitan pizza, captured in every frame.
Catering For Every Occasion
Freshly prepared, professionally organized, and ready to serve—so your event feels effortless and memorable from start to finish. Let us handle the food while you focus on your guests. Our catering brings authentic wood-fired craftsmanship straight from the oven to your event, whether it’s a corporate lunch, family celebration, birthday party, or special occasion.
A Place For Everyone
Whether you're gathering with family, meeting friends, or planning a casual night out, there’s space and comfort for all. Enjoy relaxed outdoor seating, convenient high chairs for little ones, flavorful vegetarian options, a private dining room for special occasions, and a welcoming atmosphere that’s great for watching sports.
Visit Us Today!! 🍕
Stop by and experience authentic wood-fired Italian craftsmanship at a location near you. We’re conveniently located at 635 U.S. Highway 1 in North Palm Beach, 1012 4th Avenue North in Nashville, 8129 Sawyer Brown Road in Bellevue, 4959 Santa Monica Boulevard in Los Angeles, and across Austin at 301 Lavaca Street Suite 200, 8000 Burnet Road, and 5701 West Slaughter Lane. Wherever you join us, you’ll find the same dedication to quality, tradition, and exceptional service.
What our guests are saying
We love the Santo pizzeria. Picture below is the carnival with sausage. The crust was stuffed with fresh ricotta cheese. It was out of this world and I’ve had my share of good pizzas. I put that up with the turf club in Port Chester New York’s Pizza I gave it 10 out of 10. It’s definitely someplace you want to go to . we dine in we had 10 people, it was really busy. Brett was doing a great job. Atmosphere there is very relaxed.10 out of 10
Joe F.
The pizza was delicious! Everything was fresh and the Margarita was awesome! 10/10 would recommend! Went back for a second/third and fourth time and this place is just great! The meatballs were fantastic homemade and fresh. The sausage on the pizza is unbelievable and the prosciutto pizza 👌must try!
Arran630
This is my new favorite pizza spot! The dough was perfectly crisp, and I ordered the NY-style pizza…it had the most delicious garlicky flavor. So good. I will be coming back to try more items on the menu.
Sylvia G.
Featuring
Outdoor Seating
High Chairs
DeSano Pizzeria Napoletana Rewards
Join our rewards program, earn points every time you order online, and redeem your points for free food!
Frequently Asked Questions
What are you known for?
We are known for Salads, Lasagna, Neapolitan Pizza, Focaccia, Italian Food, Calzone, Cannoli, Caprese, Bruschetta, Gelato, Cacio E Pepe, and Meatballs
What areas do you serve?
We serve the following areas: North Palm Beach, Lake Park, Riviera Beach, Juno Ridge, Monet, Palm Beach Shores, Cabana Colony, Mangonia Park, West Palm Beach, Juno Beach, Palm Beach Gardens, Lakeside Green, Jupiter, Cypress Lakes, Military Park, Schall Circle, Century Village, Westgate, Palm Beach, West Jupiter.
